There are events the place festivities abound and, a few drinks later, our heads pound. Some people marvel if it’s unhealthy to take acetaminophen, further typically known as Tylenol®, for a headache after ingesting alcohol.
Hepatologist Christina Lindenmeyer, MD, has the options.
How does your liver course of medication and alcohol?
As a result of it does for lots of medication, your physique metabolizes acetaminophen inside the liver. Everytime you take the actually helpful dosage, most of it is remodeled by your liver proper right into a benign substance that’s eradicated in your urine.
Your physique converts a extremely small byproduct of metabolized acetaminophen proper into a toxic substance which may be harmful to your liver. Happily, a secondary substance known as glutathione helps scale back the toxic outcomes.
Nonetheless, whenever you take an extreme quantity of acetaminophen, or if the liver would not have an plentiful reserve of glutathione, the toxic metabolite can accumulate and set off important hurt to your liver.
Alcohol may also be metabolized by liver cells. In reality, every acetaminophen and alcohol take advantage of glutathione inside the liver to temper their toxic outcomes.
“Over time, persistent, heavy alcohol consumption depletes your liver of its glutathione retailers, which can lead to points when acetaminophen is added to the combo,” Dr. Lindenmeyer says.
Will Tylenol after a few drinks harm your liver?
Often, taking a standard dose of acetaminophen (no more than 4,000 mg in a day) after one night of ingesting should not set off liver hurt. Nonetheless, frequent, heavy alcohol use (a few drink day-to-day for women or better than two drinks day-to-day for males) combined with repeated day-to-day doses of acetaminophen predisposes the liver to acetaminophen-associated toxicity.
Usually, whenever you’re going to drink at a celebration or completely different social event and you take a couple of doses of acetaminophen the next day to your headache (as soon as extra, no more than 4000 mg in a day), you must be optimistic.
Nonetheless, whenever you recurrently drink better than the actually helpful number of alcoholic drinks per day, you’d be biggest off to solely use acetaminophen in unusual conditions and stay away from day-to-day doses greater than 4,000 mg.